Decades ago, the introduction of nicotine and contraceptive transdermal patches offered a convenient method for delivering substances like nicotine and hormones directly into the bloodstream. Initially, there was hope that a similar approach could be used for delivering vitamins, but a significant obstacle emerged.
Vitamin molecules are too large to pass through the skin barrier without help.
To overcome this challenge, a new technology had to be developed to enable the transdermal delivery of vitamins.
FINALLY, in recent years, such technology emerged in the form of microneedles, which enhance skin permeability. This breakthrough has opened up the possibility of using transdermal routes for essential vitamins.